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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Infliximab

5

XVII.h Nontuberculous pulmonary mycobacterial infection/superinfection

2
Last update : 30/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Biosimilars
1
Infliximab biosimilar
1
TNF-alpha antagonists / inhibitors
5

Publications

Disseminated Mycobacterium haemophilum infection in a 72-year-old patient with rheumatoid arthritis on infliximab.
BMJ case reports 2013 Mar 15;2013; 2013 Mar 15
Rapid growing mycobacteria and TNF-α blockers: case report of a fatal lung infection with Mycobacterium abscessus in a patient treated with infliximab, and literature review.
Clinical and experimental rheumatology 2011;29;705-7 2011

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