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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Infliximab

5

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 23/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Biosimilars
1
Infliximab biosimilar
1
TNF-alpha antagonists / inhibitors
5

Publications

Infliximab in inflammatory bowel disease: attention to adverse events.
European review for medical and pharmacological sciences 2014 Aug;18;2337-42 2014 Aug
Asthma unmasked with tumor necrosis factor-α-blocking drugs.
Chest 2011 Oct;140;1068-1071 2011 Oct
Bronchospasm associated with anti-TNF treatment.
Clinical rheumatology 2009 Aug;28;989-92 2009 Aug

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