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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Infliximab

5

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

2
Last update : 18/06/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Biosimilars
1
Infliximab biosimilar
1
TNF-alpha antagonists / inhibitors
5

Publications

Infliximab in inflammatory bowel disease: attention to adverse events.
European review for medical and pharmacological sciences 2014 Aug;18;2337-42 2014 Aug
Safety of infliximab in Crohn's disease: a large single-center experience.
Inflammatory bowel diseases 2010 Dec;16;2109-16 2010 Dec
Severe anaphylactic reaction during the second infusion of infliximab in a patient with psoriatic arthritis.
Allergologia et immunopathologia 2005;33;291-2 2005
Severe anaphylactic reaction to infliximab: successful treatment with adalimumab - report of a case.
European journal of gastroenterology & hepatology 2004 Jun;16;627-30 2004 Jun
The incidence and management of infusion reactions to infliximab: a large center experience.
The American journal of gastroenterology 2003 Jun;98;1315-24 2003 Jun

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