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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Hyaluronic acid inhection for laryngoplasty)
1
VIII.c
Upper airway obstruction other than angioedema or hematoma
1
Last update :
30/03/2019
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
More detailed checklist
Publications
Inflammatory Reactions to Laryngeal Injection of Hyaluronic Acid Derivatives.
Adverse Reaction to Restylane: A Review of 63 Cases of Injection Laryngoplasty.