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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Elosulfase A

1

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1
Last update : 03/03/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Anaphylaxis after Elosulfase A infusion: Omalizumab as coadjuvant for enzyme replacement therapy desensitization.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2019 Jun;30;491-494 2019 Jun

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