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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Imipramine

2

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

2
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Lung as reservoir for antidepressants in pharmacokinetic drug interactions.
Lancet (London, England) 1998 Jan 31;351;332-5 1998 Jan 31
Loeffler's syndrome: an uncommon adverse reaction to imipramine.
International clinical psychopharmacology 1986 Jul;1;260-2 1986 Jul
Proven asymptomatic eosinophilia with imipramine.
The American journal of psychiatry 1977 Nov;134;1296-7 1977 Nov
Loeffler's syndrome occurring during imipramine therapy.
The American journal of psychiatry 1963 Mar;119;892-3 1963 Mar
Extreme eosinophilia during imipramine therapy.
The American journal of psychiatry 1961 Aug;118;170-1 1961 Aug

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