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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ibuprofen

3

VI.y Pulmonary hypertension of the newborn (Persistent PHT)

1
Last update : 04/03/2016
 
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Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Nonsteroidal anti-inflammatory drugs (NSAIDs)
5

Publications

Pulmonary Arterial Hypertension after Ibuprofen Treatment for Patent Ductus Arteriosus in Very Low Birth Weight Infants.
The Journal of pediatrics 2016 Dec;179;49-53.e1 2016 Dec
Lethal pulmonary hypertension associated with ibuprofen treatment in a very low birth weight infant.
Journal of paediatrics and child health 2014 Jan;50;85-6 2014 Jan
Severe pulmonary hypertension with therapeutic L-lysine ibuprofen in 2 preterm neonates.
Pediatrics 2012 May;129;e1360-3 2012 May
Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2006 Jun 20;174;1843-4 2006 Jun 20

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