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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ibuprofen

3

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1
Last update : 22/08/2012
 
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Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Nonsteroidal anti-inflammatory drugs (NSAIDs)
5

Publications

Pulmonary infiltrates with eosinophilia syndrome in ibuprofen overdose.
The New Zealand medical journal 2012 Aug 24;125;74-5 2012 Aug 24
Ibuprofen-induced eosinophilic pneumonia.
Hospital medicine (London, England : 1998) 2004 Apr;65;241 2004 Apr
Nonsteroidal anti-inflammatory drug-associated pulmonary infiltrates with eosinophilia. Review of the literature and Food and Drug Administration Adverse Drug Reaction reports.
Archives of internal medicine 1992 Jul;152;1521-4 1992 Jul

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