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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Ibuprofen
3
IV.a
Bronchospasm - Wheezing - Asthma
1
Last update :
07/09/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Publications
Nonsteroidal anti-inflammatory drug hypersensitivity in a pediatric severe asthmatic population.
Risk of acute exacerbation between acetaminophen and ibuprofen in children with asthma.
Short-term ibuprofen treatment and pulmonary function in children with asthma.
How safe is ibuprofen in febrile asthmatic children?
Asthma death induced by ibuprofen.