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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hydroxyurea (hydroxycarbamide)

2

I.b Pneumonitis (ILD)

2
Last update : 09/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

A 66-year-old man with hydroxycarbamide induced pneumonitis.
The Netherlands journal of medicine 2018 Aug;76;298-301 2018 Aug
Hydroxyurea-Induced Interstitial Pneumonitis: A Rare Clinical Entity.
Kansas journal of medicine 2017 May;10;47-49 2017 May
[Hydrocycarbamide induced fever: four cases and literature review].
La Revue de medecine interne 2015 Feb;36;73-7 2015 Feb
[Hydroxyurea-induced pneumonia].
Revue des maladies respiratoires 2014 May;31;430-4 2014 May
Hydroxyurea-induced interstitial pneumonitis: case report and review of the literature.
European review for medical and pharmacological sciences 2014;18;190-3 2014
Hydroxyurea-induced pneumonitis in a patient with chronic idiopathic myelofibrosis after prolonged drug exposure.
European journal of haematology 2003 Nov;71;388-90 2003 Nov
[Hydroxyurea-induced pneumonitis].
Medizinische Klinik (Munich, Germany : 1983) 2003 Jul 15;98;394-7 2003 Jul 15
Hydroxyurea-induced hypersensitivity pneumonitis: A case report and literature review.
Canadian respiratory journal 2000;7;491-5 2000
Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia.
Annals of hematology 1999 Apr;78;187-8 1999 Apr
Recurrent pyrexia, cough and dyspnoea with hydroxyurea.
Australian and New Zealand journal of medicine 1998 Jun;28;347 1998 Jun
Hydroxyurea-induced acute alveolitis in a patient with chronic myeloid leukaemia.
Cancer chemotherapy and pharmacology 1990;27;168-9 1990

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