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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hydroxyurea (hydroxycarbamide)

2

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1
Last update : 21/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Hydroxyurea-Induced Pneumopathy in a Patient With Myeloproliferative Syndrome.
Clinical medicine insights. Case reports 2018;11;1179547618770688 2018
[Hydroxyurea-induced pneumonia].
Revue des maladies respiratoires 2014 May;31;430-4 2014 May
[Acute interstitial pneumopathy with fever caused by hydroxyurea].
Presse medicale (Paris, France : 1983) 2000 Feb 12;29;242-5 2000 Feb 12
Hydroxyurea-induced acute interstitial lung disease.
Southern medical journal 1994 Jul;87;767-9 1994 Jul
Acute alveolitis induced by hydroxyurea in a patient with myeloproliferative syndrome.
Annals of hematology 1993 Sep;67;133-4 1993 Sep
Hydroxyurea-induced acute alveolitis in a patient with chronic myeloid leukaemia.
Cancer chemotherapy and pharmacology 1990;27;168-9 1990

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