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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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CAR T-cell therapy

4

XVII.b Opportunistic pulmonary/systemic infections

3
Last update : 12/09/2023
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Infectious complications of car T-cell therapy: A longitudinal risk model.
Transplant infectious disease : an official journal of the Transplantation Society 2023 Nov;25 Suppl 1;e14148 2023 Nov

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