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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Hydrochlorothiazide
3
II.i
Flash (fulminate) pulmonary edema
1
May develop after first exposure to one single pill/tablet of drug
Last update :
07/01/2014
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
Publications
When a Diuretic Causes Pulmonary Oedema.
Hydrochlorothiazide-induced pulmonary edema and associated immunologic changes.
Hydrochlorothiazide-induced acute pulmonary edema.
[Hydrochlorothiazide-induced lung edema with shock].
Noncardiogenic pulmonary edema following hydrochlorothiazide ingestion.
Hydrochlorothiazide-induced pulmonary edema. Report of a case and review of the literature.