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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hydralazine

4

X.m Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)

1
Last update : 21/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Systemic vasculitis resembling periarteritis nodosa in the lupus-like syndrome induced by hydralazine.
American journal of nephrology 1987;7;71-3 1987
Hydralazine-induced necrotising vasculitis.
British medical journal (Clinical research ed.) 1981 Apr 04;282;1121-2 1981 Apr 04
Rheumatic and febrile syndrome during prolonged hydralazine treatment.
Journal of the American Medical Association 1954 Jan 02;154;23-9 1954 Jan 02

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