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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hydralazine

4

XII.k Constrictive pericarditis - Pericardial thickening

1
Last update : 21/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Hydralazine-induced constrictive pericarditis.
The Netherlands journal of medicine 1996 May;48;193-7 1996 May
Constrictive pericarditis due to hydralazine-induced lupus erythematosus.
The American journal of medicine 1990 Jan;88;56N-59N 1990 Jan

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