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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hydralazine

4

XII.c Pericardial effusion (w/wo tamponade)

1
Last update : 21/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

ANA-Negative Hydralazine-Induced Pericardial Effusion.
Case reports in medicine 2017;2017;3521541 2017
Isoniazid-induced lupus erythematosus presenting with cardiac tamponade.
American journal of therapeutics 2002;9;163-5 2002
Pericardial tamponade: a major presenting manifestation of hydralazine-induced lupus syndrome.
The American journal of medicine 1973 Jan;54;84-7 1973 Jan
Rheumatic and febrile syndrome during prolonged hydralazine treatment.
Journal of the American Medical Association 1954 Jan 02;154;23-9 1954 Jan 02

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