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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hydralazine

4

X.s Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

2
Last update : 21/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Overlapping drug-induced vasculitis, ANCA-associated vasculitis, and lupus nephritis caused by low-dose hydralazine.
International journal of rheumatic diseases 2023 Nov;26;2272-2277 2023 Nov
Diagnostic dilemma: drug-induced vasculitis versus systemic vasculitis.
BMJ case reports 2023 Jul 10;16; 2023 Jul 10
The Utility of Bronchoscopy in Hydralazine-Induced ANCA-Associated Vasculitis.
Case reports in pulmonology 2023;2023;1461011 2023
Rare complication of a commonly used antihypertensive agent: A case of hydralazine-induced ANCA-associated vasculitis presenting as rapidly progressive glomerulonephritis.
Clinical case reports 2022 Feb;10;e05411 2022 Feb
Fulminant Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis After 10 Years of Hydralazine Use.
Cureus 2021 Oct;13;e18974 2021 Oct
Hydralazine-Induced ANCA Associated Vasculitis (AAV) Presenting with Pulmonary-Renal Syndrome (PRS): A Case Report with Literature Review.
Current cardiology reviews 2021;17;182-187 2021
Antineutrophil cytoplasmic antibody vasculitis induced by hydralazine.
Cutis 2020 Jan;105;E32-E35 2020 Jan
An intriguing case of anemia and renal failure.
Proceedings (Baylor University. Medical Center) 2019 Jan;32;78-79 2019 Jan
Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 2019;30;226-230 2019
Hydralazine-associated adverse events: a report of two cases of hydralazine-induced ANCA vasculitis.
Jornal brasileiro de nefrologia 2018;40;193-197 2018
Hydralazine-induced pauci-immune glomerulonephritis: intriguing case series with misleading diagnoses.
Journal of community hospital internal medicine perspectives 2016;6;30632 2016
Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Current opinion in rheumatology 2014 Jan;26;42-9 2014 Jan
Hydralazine induces myeloperoxidase and proteinase 3 anti-neutrophil cytoplasmic antibody vasculitis and leads to pulmonary renal syndrome.
Case reports in nephrology 2014;2014;868590 2014
Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis presenting with a vasculitic syndrome, acute nephritis and a puzzling skin rash: a case report.
Journal of medical case reports 2013 Jan 14;7;20 2013 Jan 14
Hydralazine-induced ANCA vasculitis with pulmonary renal syndrome: a rare clinical presentation.
International urology and nephrology 2012 Dec;44;1907-9 2012 Dec
Combined ANCA-associated vasculitis and lupus syndrome following prolonged use of hydralazine: a timely reminder of an old foe.
International urology and nephrology 2010 Jun;42;503-6 2010 Jun
Hydralazine-induced ANCA-positive pauci-immune glomerulonephritis: a case report and literature review.
Renal failure 2009;31;745-8 2009
Hydralazine-induced autoimmune disease: comparison to idiopathic lupus and ANCA-positive vasculitis.
Modern rheumatology 2009;19;338-47 2009
Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies.
Arthritis and rheumatism 2000 Feb;43;405-13 2000 Feb
Antigen specificity in hydralazine associated ANCA positive systemic vasculitis.
QJM : monthly journal of the Association of Physicians 1995 Nov;88;775-83 1995 Nov

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