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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hydralazine

4

X.e Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)

2
Last update : 21/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

The Utility of Bronchoscopy in Hydralazine-Induced ANCA-Associated Vasculitis.
Case reports in pulmonology 2023;2023;1461011 2023
Hydralazine-induced antineutrophil cytoplasmic antibody-associated vasculitis with pulmonary-renal syndrome: a case report.
Journal of medical case reports 2020 Apr 15;14;47 2020 Apr 15
Clinical Characteristics of Hydralazine-induced Lupus.
Cureus 2019 Jun 25;11;e4996 2019 Jun 25
An intriguing case of anemia and renal failure.
Proceedings (Baylor University. Medical Center) 2019 Jan;32;78-79 2019 Jan
Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 2019;30;226-230 2019
Hydralazine-induced autoimmune disease: comparison to idiopathic lupus and ANCA-positive vasculitis.
Modern rheumatology 2009;19;338-47 2009
Rheumatoid arthritis-like syndrome during apresoline therapy: report of a case.
The Medical annals of the District of Columbia 1953 Dec;22;651-2 1953 Dec

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