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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Lorlatinib

1

VI.b Pulmonary arterial hypertension

1
Last update : 12/05/2018
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Post-marketing safety of lorlatinib: a real-world study based on the FDA adverse event reporting system.
Frontiers in pharmacology 2024;15;1385036 2024
Lorlatinib - Induced pulmonary arterial hypertension.
Lung cancer (Amsterdam, Netherlands) 2018 Jun;120;60-61 2018 Jun

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