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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Mitomycin (intracavitary in the urinary bladder)

2

I.b Pneumonitis (ILD)

1
Last update : 26/02/2018
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Interstitial pneumonitis and myelosuppression associated to mitomycin C urinary tract instillations: A case report.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2019 Apr;25;739-742 2019 Apr
Intravesical mitomycin-C-induced interstitial pneumonia.
Respiration; international review of thoracic diseases 2010;80;256-9 2010
[Lung parenchyma disease following instillation of mitomycin C in the bladder].
Deutsche medizinische Wochenschrift (1946) 1986 Oct 10;111;1564-6 1986 Oct 10

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