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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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G/GM-CSF

3

IV.f Severe or catastrophic bronchospasm or asthma attack (can be fatal)

1
Last update : 23/04/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Subcutaneous granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndrome: toxicity, pharmacokinetics, and hematological effects.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989 May;7;629-37 1989 May

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