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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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G/GM-CSF

3

II.f Hypoxemia, low oxygen saturation (may occur in isolation)

2
Last update : 01/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation.
Transfusion 2006 Feb;46;186-92 2006 Feb
Adverse side-effects associated with G-CSF in patients with chronic myeloid leukemia undergoing allogeneic peripheral blood stem cell transplantation.
Bone marrow transplantation 2000 Jun;25;1197-201 2000 Jun
Impairment in gas exchange after granulocyte colony stimulating factor (G-CSF) in a patient with the adult respiratory distress syndrome.
Chest 1995 Jan;107;276-8 1995 Jan
Phase I trial of recombinant granulocyte-macrophage colony-stimulating factor in patients with lung cancer: clinical and immunologic effects.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993 May 04;13;267-74 1993 May 04
Characterization of the clinical effects after the first dose of bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor.
Blood 1989 Dec;74;2634-43 1989 Dec

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