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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Antimalarial drugs-Antimalarials
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XII.ai
Cardiotoxicity
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Last update :
22/01/2017
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dapsone (diaminophenylsulfone)
Malaria prophylaxis
Pyrimethamine-dapsone
Quinine
Publications
Cardiomyopathy related to antimalarial therapy with illustrative case report.
