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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gemcitabine

5

XVI.b Imaging: Ground-glass opacities (GGO) / shadowing

1
Last update : 17/03/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

A case of late-onset gemcitabine lung toxicity.
Clinical Medicine Insights. Oncology 2011;5;171-6 2011
Severe pulmonary toxicity in patients with leiomyosarcoma after treatment with gemcitabine and docetaxel.
Investigational new drugs 2007 Jun;25;279-81 2007 Jun
Severe pulmonary toxicity in a patient treated with gemcitabine.
American journal of clinical oncology 2002 Feb;25;31-3 2002 Feb
Gemcitabine pulmonary toxicity: CT features.
Journal of computer assisted tomography 2000;24;977-80 2000

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