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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gemcitabine

5

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1
Last update : 11/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Aetiologies and outcomes of diffuse alveolar haemorrhage presenting as acute respiratory failure of uncertain cause.
Respirology (Carlton, Vic.) 2009 Mar;14;290-4 2009 Mar
[A case of non-small cell lung cancer accompanied with hemorrhage after chemotherapy including gemcitabine].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2006 Mar;44;215-9 2006 Mar
Gemcitabine-associated diffuse alveolar hemorrhage.
Intensive care medicine 2001 Sep;27;1554 2001 Sep
Fatal pulmonary toxicity resulting from treatment with gemcitabine.
Cancer 1997 Jul 15;80;286-91 1997 Jul 15

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