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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gemcitabine

5

II.b ARDS - Acute lung injury

4
Last update : 18/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Acute respiratory distress syndrome mimickers lacking common risk factors of the Berlin definition.
Intensive care medicine 2016 Feb;42;164-72 2016 Feb
Separate episodes of capillary leak syndrome and pulmonary hypertension after adjuvant gemcitabine and three years later after nab-paclitaxel for metastatic disease.
BMC cancer 2013 Nov 12;13;542 2013 Nov 12
Gemcitabine-induced pulmonary toxicity.
Anticancer research 2012 Sep;32;4147-9 2012 Sep
Drug-associated acute lung injury: a population-based cohort study.
Chest 2012 Oct;142;845-850 2012 Oct
[Interstitial pneumonitis due to gemcitabine].
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 2012;36;452-3 2012
Clinical features and correlates of gemcitabine-associated lung injury: findings from the RADAR project.
Cancer 2006 May 01;106;2051-7 2006 May 01
Gemcitabine-induced respiratory failure associated with elevated erythrocyte sedimentation rate (ESR).
Respiratory medicine 2006 Apr;100;760-3 2006 Apr
Gemcitabine-induced severe pulmonary toxicity.
Fundamental & clinical pharmacology 2004 Feb;18;85-91 2004 Feb
Severe pulmonary toxicity in a patient treated with gemcitabine.
American journal of clinical oncology 2002 Feb;25;31-3 2002 Feb
Severe non-haematological toxicity after treatment with gemcitabine.
Journal of cancer research and clinical oncology 1999 Nov;125;637-40 1999 Nov
Successful treatment of gemcitabine toxicity with a brief course of oral corticosteroid therapy.
Chest 1998 Dec;114;1779-81 1998 Dec

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