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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gemcitabine

5

II.a Pulmonary edema, noncardiogenic (NCPE)

2
Last update : 18/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Gemcitabine-induced respiratory failure associated with elevated erythrocyte sedimentation rate (ESR).
Respiratory medicine 2006 Apr;100;760-3 2006 Apr
[Hemolytic uremic syndrome as a complication of gemcitabine treatment: report of six cases and review of the literature].
La Revue de medecine interne 2005 Mar;26;179-88 2005 Mar
Fatal pulmonary toxicity resulting from treatment with gemcitabine.
Cancer 1998 May 01;82;1800-1 1998 May 01

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