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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gemcitabine

5

XV.f Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

1
Last update : 13/08/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Severe pulmonary toxicity in patients with leiomyosarcoma after treatment with gemcitabine and docetaxel.
Investigational new drugs 2007 Jun;25;279-81 2007 Jun
Causes and prognosis of diffuse alveolar damage diagnosed on surgical lung biopsy.
Chest 2007 Jul;132;50-7 2007 Jul
[A case of non-small cell lung cancer accompanied with hemorrhage after chemotherapy including gemcitabine].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2006 Mar;44;215-9 2006 Mar
An autopsy case of acute pulmonary toxicity associated with gemcitabine.
Internal medicine (Tokyo, Japan) 2003 Oct;42;1022-5 2003 Oct

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