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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gemcitabine

5

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2
Last update : 11/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Clinical features and correlates of gemcitabine-associated lung injury: findings from the RADAR project.
Cancer 2006 May 01;106;2051-7 2006 May 01
Hypersensitivity pneumonitis in advanced non-small-cell lung cancer patients receiving gemcitabine and paclitaxel: report of two cases and a review of the literature.
Clinical lung cancer 2002 Jul;4;52-6 2002 Jul
[Interstitial lung disease in a patient given gemcitabine].
Revue de pneumologie clinique 2002 Feb;58;23-6 2002 Feb
Side effects of chemotherapy. Case 3. Acute interstitial pneumonitis related to gemcitabine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000 Feb;18;697-8 2000 Feb

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