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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gemcitabine

5

X.c Capillary leak syndrome (CLS)

1
Last update : 15/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Separate episodes of capillary leak syndrome and pulmonary hypertension after adjuvant gemcitabine and three years later after nab-paclitaxel for metastatic disease.
BMC cancer 2013 Nov 12;13;542 2013 Nov 12
Cure of gemcitabine-induced systemic capillary leak syndrome without corticosteroids.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2009;14;728-9 2009
Gemcitabine: vascular toxicity and prothrombotic potential.
Expert opinion on drug safety 2008 Nov;7;703-16 2008 Nov
Gemcitabine-induced chronic systemic capillary leak syndrome: a life-threatening disease.
Clinical oncology (Royal College of Radiologists (Great Britain)) 2006 Feb;18;90-1 2006 Feb
Severe gemcitabine-induced capillary-leak syndrome mimicking cardiac failure in a patient with advanced pancreatic cancer and high-risk cardiovascular disease.
Clinical oncology (Royal College of Radiologists (Great Britain)) 2004 Dec;16;577-9 2004 Dec
Gemcitabine-induced systemic capillary leak syndrome.
Annals of oncology : official journal of the European Society for Medical Oncology 2001 Nov;12;1651-2 2001 Nov

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