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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Atezolizumab

2

X.k Sarcoid-like granulomatosis (endo-/extrathoracic)

1
Last update : 18/10/2018
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5

Publications

Sarcoidosis-like reaction in metastatic triple negative breast cancer treated by anti-PD-L1.
The breast journal 2019 Sep;25;971-973 2019 Sep
Atezolizumab-induced sarcoid-like granulomatous reaction in a patient with urothelial cell carcinoma.
Immunotherapy 2018 Oct;10;1189-1192 2018 Oct

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