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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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CTLA4 blocking immunotherapy

3

I.b Pneumonitis (ILD)

1
Last update : 10/10/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Ipilimumab
4
Tremelimumab
1

Publications

Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study.
The Lancet. Oncology 2016 Mar;17;299-308 2016 Mar

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