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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Fluorouracil (5-FU)

3

XII.af Coronary vasospasm - Vasospastic angina

2
Last update : 20/04/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil.
Case reports in oncological medicine 2020;2020;4151474 2020
5-Fluorouracil-Associated Coronary Vasospasm in a Patient With Metastatic Adenocarcinoma of the Esophagus.
American journal of therapeutics 2019;26;e664-e668 2019
5-fluorouracil and cardiotoxicity: a review.
Therapeutic advances in medical oncology 2018;10;1758835918780140 2018
Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease.
Bulletin du cancer 2006 Mar 01;93;E27-30 2006 Mar 01
Prinzmetal's angina during 5-fluorouracil chemotherapy.
The American journal of medicine 1987 Mar;82;566-8 1987 Mar

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