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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Fluorouracil (5-FU)

3

XII.a Left or biventricular dysfunction/failure

1
Last update : 14/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Acute reversible left ventricular systolic dysfunction associated with 5-fluorouracil therapy: a rare and increasingly recognised cardiotoxicity of a commonly used drug.
BMJ case reports 2019 Sep 12;12; 2019 Sep 12
5-Fluorouracil-induced acute reversible heart failure not explained by coronary spasms, myocarditis or takotsubo: lessons from MRI.
BMJ case reports 2016 Jun 01;2016; 2016 Jun 01
5-Fluorouracil cardiotoxicity: reversible left ventricular systolic dysfunction with early detection.
BMJ case reports 2015 May 02;2015; 2015 May 02
Acute Reversible Heart Failure Caused by Coronary Vasoconstriction due to Continuous 5-Fluorouracil Combination Chemotherapy.
Case reports in oncology 2012 May;5;296-301 2012 May
[Cardiotoxicity of 5-fluorouracil: report of 6 cases].
Therapie 2002;57;302-6 2002

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