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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Fluorouracil (5-FU)

3

XII.g Coronary artery disease (acute) - Myocardial ischemia/infarction

2
Last update : 10/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

5-fluorouracil and cardiotoxicity: a review.
Therapeutic advances in medical oncology 2018;10;1758835918780140 2018
5-Fluorouracil cardiotoxicity: reversible left ventricular systolic dysfunction with early detection.
BMJ case reports 2015 May 02;2015; 2015 May 02
5-fluorouracil induced pericarditis.
BMJ case reports 2011 Apr 15;2011; 2011 Apr 15
Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease.
Bulletin du cancer 2006 Mar 01;93;E27-30 2006 Mar 01
[Cardiotoxicity of 5-fluorouracil: report of 6 cases].
Therapie 2002;57;302-6 2002
Clinical cardiotoxicity of 5-fluorouracil.
Journal of clinical pharmacology 1993 Nov;33;1060-70 1993 Nov
Cardiac arrest--a manifestation of 5-fluorouracil cardiotoxicity.
Australian and New Zealand journal of medicine 1988 Aug;18;693-5 1988 Aug

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