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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Fluorouracil (5-FU)

3

XI.b Chest pain (acute or subacute), lone or prominent

2
Last update : 22/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

5-fluorouracil and cardiotoxicity: a review.
Therapeutic advances in medical oncology 2018;10;1758835918780140 2018
[Cardiotoxicity of 5-fluorouracil: report of 6 cases].
Therapie 2002;57;302-6 2002
5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report.
BMC cardiovascular disorders 2001;1;3 2001
5-Fluorouracil cardiotoxicity: a critical review.
Annals of oncology : official journal of the European Society for Medical Oncology 1990 Nov;1;409-14 1990 Nov

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