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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Fluorouracil (5-FU)

3

I.g Pulmonary fibrosis

1
Last update : 14/03/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Interstitial fibrosis in a patient treated with 5-fluorouracil and mitomycin C.
British medical journal 1979 Sep 01;2;551-2 1979 Sep 01

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