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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Osimertinib

4

XII.l Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

1
Last update : 05/01/2024
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Fatal ventricular arrhythmias after osimertinib treatment for lung adenocarcinoma: a case report.
Journal of geriatric cardiology : JGC 2023 Mar 28;20;242-246 2023 Mar 28

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