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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Busulfan + Melphalan regimen

1

VI.b Pulmonary arterial hypertension

1
Last update : 11/05/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Busulfan
5
Melphalan
3

Publications

Toxicities of busulfan/melphalan versus carboplatin/etoposide/melphalan for high-dose chemotherapy with stem cell rescue for high-risk neuroblastoma.
Bone marrow transplantation 2016 Sep;51;1204-10 2016 Sep

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