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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Benzonatate

1

XI.d Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

1
Last update : 05/05/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Cardiac Arrest Due to Benzonatate Overdose.
The American journal of case reports 2019 May 03;20;640-642 2019 May 03
Benzonatate toxicity in a teenager resulting in coma, seizures, and severe metabolic acidosis.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 2012 Jul;17;270-3 2012 Jul

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