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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Antiplatelet (-P2Y) agents

3

IX.h Dyspnea, unexplained otherwise

3
Last update : 21/09/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Ticagrelor
5

Publications

Dyspnea related to reversibly-binding P2Y12 inhibitors: A review of the pathophysiology, clinical presentation and diagnostics.
International journal of cardiology 2016 Jan 01;202;167-73 2016 Jan 01
Dyspnea and reversibility of antiplatelet agents: ticagrelor, elinogrel, cangrelor, and beyond.
Cardiology 2014;127;20-4 2014
Viewpoint: reversible nature of platelet binding causing transfusion-related acute lung injury (TRALI) syndrome may explain dyspnea after ticagrelor and elinogrel.
Thrombosis and haemostasis 2012 Dec;108;1024-7 2012 Dec

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