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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Fentanyl

5

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

2
Last update : 08/06/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Acetylfentanyl
1
Butyrfentanyl
2
Carfentanyl (carboxymethoxyfentanyl)
2
Fentanyl (smoked, snorted, insufflated, inhaled)
2
Fentanyl (topical)
3
Fentanyl analogs/derivatives/substituted
5
Opiates - Opioids - Opium
5

Publications

Risk factors for bradypnea in a historical cohort of surgical patients receiving fentanyl-based intravenous analgesia.
JA clinical reports 2018 Jun 13;4;46 2018 Jun 13
Abuse of fentanyl: An emerging problem to face.
Forensic science international 2018 Aug;289;207-214 2018 Aug
Multiple Fentanyl Overdoses - New Haven, Connecticut, June 23, 2016.
MMWR. Morbidity and mortality weekly report 2017 Feb 03;66;107-111 2017 Feb 03
A Costly Lesson: Fatal Respiratory Depression Induced by Clindamycin during Postoperative Patient Controlled Analgesia.
Pain physician 2015;18;E429-31 2015
Recurrent respiratory depression associated with fentanyl transdermal patch gel reservoir ingestion.
The Journal of emergency medicine 2012 May;42;543-8 2012 May
Suspected respiratory depression associated with use of transdermal fentanyl patch.
Pain physician 2012;15;E536-7 2012
Rectal insertion of fentanyl patches: a new route of toxicity.
Annals of emergency medicine 2005 Nov;46;473 2005 Nov
Respiratory arrest after low-dose fentanyl.
Annals of Saudi medicine 2005;25;508-10 2005
Opioid-induced respiratory depression: a mathematical model for fentanyl.
IEEE transactions on bio-medical engineering 2004 Jul;51;1115-28 2004 Jul
[Acute poisoning during substitution therapy based on high-dosage buprenorphine. 29 clinical cases--20 fatal cases].
Presse medicale (Paris, France : 1983) 1998 Mar 28;27;557-61 1998 Mar 28

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