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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Loperamide

3

XII.l Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

1
Last update : 25/08/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Loperamide-Induced Cardiac Events: Case Reports and Review.
Cureus 2021 Dec;13;e20744 2021 Dec
Loperamide Toxicity Revealing Apical Hypertrophic Cardiomyopathy.
Methodist DeBakey cardiovascular journal 2021 Apr 05;17;65-67 2021 Apr 05
Loperamide: A Readily Available but Dangerous Opioid Substitute.
Journal of clinical pharmacology 2019 Sep;59;1165-1169 2019 Sep
Loperamide abuse cardiotoxicity. Should loperamide still be an over the counter medication?
The American journal of emergency medicine 2018 Sep;36;1716.e1-1716.e3 2018 Sep
Loperamide abuse and cardiotoxicity.
Journal of community hospital internal medicine perspectives 2017 Oct;7;275 2017 Oct
Loperamide Trends in Abuse and Misuse Over 13 Years: 2002-2015.
Pharmacotherapy 2017 Feb;37;249-253 2017 Feb
Adverse event detection using the FDA post-marketing drug safety surveillance system: Cardiotoxicity associated with loperamide abuse and misuse.
Journal of the American Pharmacists Association : JAPhA 2017;57;S63-S67 2017
Loperamide Induced Life Threatening Ventricular Arrhythmia.
Case reports in cardiology 2016;2016;5040176 2016

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