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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Vedolizumab

2

XXI.b Rechallenge can lead to relapse of AE/ILD

1
Last update : 03/08/2024
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Drug-Related Pneumonitis in Patients Receiving Vedolizumab Therapy for Inflammatory Bowel Disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2022 Jun;20;e1483-e1487 2022 Jun

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