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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Etoposide
2
X.g
Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)
2
Last update :
09/08/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
Publications
[Etoposide desensitization. A case report].
Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide.
Hypersensitivity reactions to etoposide. A report of three cases and review of the literature.
Two cases of suspected immunologic-based hypersensitivity reactions to etoposide therapy.
Hypersensitivity reactions induced by etoposide.