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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Oil - Paraffin - Lipids (i.v.)
5
XIX.h
BAL: Exogenous (oil red O-stainable) lipids in BAL macrophages
3
Last update :
19/10/2018
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Oil-/lipid-based formulations (parenteral)
Paraffin-Vaseline-Oil-Lipids (Mineral or other) p.o./inhaled/aspirated
Vitamin E (parenteral)
Publications
Adult exogenous lipoid pneumonia: A rare and underrecognized entity in cytology - A case series.