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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Etanercept

4

XVII.g Tuberculosis (pulmonary, pulmonary, extrapulmonary or disseminated). Reactivation or de novo

3
Last update : 30/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
TNF-alpha antagonists / inhibitors
5

Publications

Mycobacterial diseases and antitumour necrosis factor therapy in USA.
Annals of the rheumatic diseases 2013 Jan;72;37-42 2013 Jan
Clinical image: Development of miliary tuberculosis following one intraarticular injection of etanercept.
Arthritis and rheumatism 2011 May;63;1364 2011 May
Choice of Biologic Therapy for Patients with Rheumatoid Arthritis: The Infection Perspective.
Current rheumatology reviews 2011 Feb;7;77-87 2011 Feb

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