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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Etanercept

4

I.m ILD with a granulomatous component

2
Last update : 10/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
TNF-alpha antagonists / inhibitors
5

Publications

Pulmonary Sarcoidosis following Etanercept Treatment.
Case reports in rheumatology 2012;2012;724013 2012
Sarcoidosis appearing during anti-tumor necrosis factor alpha therapy: a new "class effect" paradoxical phenomenon. Two case reports and literature review.
Seminars in arthritis and rheumatism 2010 Feb;39;313-9 2010 Feb
Pulmonary lymphohistiocytic reactions temporally related to etanercept therapy.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005 May;18;651-5 2005 May
Pulmonary granulomas after tumour necrosis factor alpha antagonist therapy.
Thorax 2003 Mar;58;278-9 2003 Mar

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