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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Etanercept
4
X.m
Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)
1
May also be a manifestation in RA unexposed to drugs
Last update :
23/11/2017
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
TNF-alpha antagonists / inhibitors
Publications
Etanercept-induced Henoch-Schönlein purpura in a patient with ankylosing spondylitis.
Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis.