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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ergots, ergot alkaloids, ergolines

4

XII.b Valvular heart disease and/or dysfunction

4
Last update : 11/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bromocriptine
3
Cabergoline
3
Dihydroergocristine
1
Dihydroergocryptine
1
Dihydroergotamine
1
Ergonovine
1
Ergotamine
2
Methysergide
2
Nicergoline
1
Pergolide
3

Publications

Drug-induced valvular heart disease: an update.
Archives of cardiovascular diseases 2013 May;106;333-9 2013 May
Ergotamine-associated valvulopathy with recurrent chylous pleural effusion.
Texas Heart Institute journal 2012;39;736-8 2012
Cardiac and noncardiac fibrotic reactions caused by ergot-and nonergot-derived dopamine agonists.
Movement disorders : official journal of the Movement Disorder Society 2009 Jan 15;24;129-33 2009 Jan 15
Drug-induced fibrotic valvular heart disease.
Lancet (London, England) 2009 Aug 15;374;577-85 2009 Aug 15
Heart valve disease associated with treatment with ergot-derived dopamine agonists: a clinical and echocardiographic study of patients with Parkinson's disease.
Journal of internal medicine 2008 Jan;263;90-8 2008 Jan
Fibrotic heart-valve reactions to dopamine-agonist treatment in Parkinson's disease.
The Lancet. Neurology 2007 Sep;6;826-9 2007 Sep
The US Food and Drug Administration's registry of patients with pergolide-associated valvular heart disease.
Mayo Clinic proceedings 2003 Jun;78;730-1 2003 Jun
Mitral valve disease associated with long-term ergotamine use.
Southern medical journal 1993 Oct;86;1179-81 1993 Oct
Valve disease associated with ergot alkaloid use: echocardiographic and pathologic correlations.
Annals of internal medicine 1992 Jul 01;117;50-2 1992 Jul 01

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